Peer reviewed Journals:
28.
Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers.
Wilding B*, Woelflingseder L, Baum A, Chylinski K, Vainorius G, Gibson N, Waizenegger IC, Gerlach D, Augsten M, Spreitzer F, Shirai Y, Ikegami M, Tilandyova S, Scharn D, Pearson MA, Popow J, Obenauf AC, Yamamoto N, Kondo S, Opdam FL, Bruining A, Kohsaka S, Kraut N, Heymach JV, Solca F, Neumuller RA*.
Cancer Discovery. 2024 Sep 9. doi: 10.1158/2159-8290.CD-24-0306. Epub ahead of print. PMID: 39248702.
(* equal contribution)
27.
Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition.
Krammer T, Stuart HT, Gromberg E, Ishihara K, Cislo D, Melchionda M, Becerril Perez F, Wang J, Costantini E, Lehr S, Arbanas L, Hörmann A, Neumüller RA, Elvassore N, Siggia E, Briscoe J, Kicheva A, Tanaka EM.
Developmental Cell. 2024 Aug 5;59(15):1940-1953.e10. doi: 10.1016/j.devcel.2024.04.021. Epub 2024 May 21. PMID: 38776925.
26.
Genetic dependencies associated with transcription factor activities in human cancer cell lines.
Thatikonda V, Supper V, Wachter J, Kaya O, Kombara A, Bilgilier C, Ravichandran MC, Lipp JJ, Sharma R, Badertscher L, Boghossian AS, Rees MG, Ronan MM, Roth JA, Grosche S, Neumüller RA, Mair B, Mauri F, Popa A.
Cell Reports. 2024 May 28;43(5):114175. doi: 10.1016/j.celrep.2024.114175. Epub 2024 Apr 30. PMID: 38691456.
25.
Precision RNAi using synthetic shRNAmir target sites.
Hoffmann T, Hörmann A, Corcokovic M, Zmajkovic J, Hinterndorfer M, Salkanovic J, Spreitzer F, Köferle A, Gitschtaler K, Popa A, Oberndorfer S, Andersch F, Schaefer M, Fellner M, Budano N, Ruppert JG, Chetta P, Wurm M, Zuber J*, Neumüller RA*.
Elife. 2023 Aug 8;12:RP84792. doi: 10.7554/eLife.84792. PMID: 37552050; PMCID: PMC10409502.
(* equal contribution)
24.
Discovery of potent and Selective HER2 Inhibitors with Efficacy Against HER2 Exon 20 Insertion-Driven Tumors which Preserve wild-type EGFR Signaling.
Birgit Wilding*, Dirk Scharn, Dietrich Böse, Anke Baum, Valeria Santoro, Paolo Chetta, Renate Schnitzer, Dana A. Botesteanu, Christoph Reiser, Stefan Kornigg, Petr Knesl, Alexandra Hörmann, Anna Köferle, Maja Corcokovic, Simone Lieb, Guido Scholz, Jens Bruchhaus, Markus Spina, Josef Balla, Biljana Peric-Simov, Jasmin Zimmer, Sophie Mitzner, Thomas N. Fett, Alexandra Beran, Lyne Lamarre, Thomas Gerstberger, Daniel Gerlach, Markus Bauer, Andreas Bergner, Andreas Schlattl, Gerd Bader, Matthias Treu, Harald Engelhardt, Stephan Zahn, Julian E. Fuchs, Johannes Zuber, Peter Ettmayer, Mark Pearson, Mark Petronczki, Norbert Kraut, Darryl B. McConnell, Flavio Solca* and Ralph A. Neumüller*
Nature Cancer 2022 July 3, 821-836.
(* equal contribution)
23.
Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sex chromosome encoded genes.
Anna Köferle, Andreas Schlattl, Alexandra Hörmann, Fiona Spreitzer, Alexandra M Popa, Venu Thatikonda, Teresa Puchner, Sarah Oberndorfer, Corinna Wieshofer, Maja Corcokovic, Christoph Reiser, Simon Wöhrle, Johannes Popow, Mark Pearson, Barbara Mair*, Ralph A Neumüller*
Cell Reports. 2022 April, 110636.
(* equal contribution)
22.
SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.
Katharina Ehrenhöfer-Wölfer, Teresa Puchner, Cornelia Schwarz, Janine Rippka, Silvia Blaha-Ostermann, Alexandra Hoermann, Ursula Strobl, Gerd Bader, Stefan Kornigg, Stephan Zahn, Wolfgang Sommergruber, Norbert Schweifer, Thomas Zichner, Andreas Schlattl, Ralph A. Neumüller, Junwei Shi, Christopher Vakoc, Manfred Koegl, Mark Petronczki, Norbert Kraut, Mark Pearson, and Simon Wöhrle.
Scientific Reports. 2019 Aug 12;9(1):11661.
21.
Fragment-based discovery of a chemical probe for the NSD3-PWWP1 domain.
Jark Böttcher, David Dilworth*, Ulrich Reiser*, Ralph A. Neumüller*, Markus Zeeb, Klaus Rumpel, Andreas Zoephel, Moriz Mayer, Tobias Wunberg, Dietrich Böse, Stephan Zahn, Nikolai Mischerikow, Helmut Berger, Christoph Reiser, Alexandra Hörmann, Teresa Krammer, Bernadette Sharps, Sandra Winkler, Daniela Haering, Xiao‑Ling Cockcroft, Julian Fuchs, Barbara Müllauer, Alexander Weiss-Puxbaum, Christopher R. Vakoc, Mark Petronczki, Michael Schleicher, Thomas Gerstberger, Guido Boehmelt, Mark Pearson, Darryl McConnell.
Nature Chemical Biology. 2019 Aug;15(8):822-829.
(* equal contribution)
20.
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Andreas Wernitznig, Jesse J. Lipp, Kota Nagasaka, Petra van der Lelij, Gerd Bader, Minoru Koi, Ajay Goel, Ralph A. Neumüller, Jan M. Peters, Norbert Kraut, Mark A. Pearson, Mark Petronczki, Simon Wöhrle.
Elife. 2019 Mar 25;8.
19.
RIOK1 kinase activity is required for cell survival irrespective of the MTAP status.
Alexandra Hoermann, Barbara Hopfgartner, Thomas Koecher, Teresa Krammer, Christoph Reiser , Gerd Bader, Junwei Shi, Norbert Schweifer, Christopher Vakoc, Norbert Kraut, Mark Pearson, Mark Petronczki and Ralph A. Neumüller.
Oncotarget. 2018 Jun 19;9(47):28625-28637.
18.
Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop.
Sebastian Wissel, Heike Harzer, François Bonnay, Thomas R. Burkard, Ralph A. Neumüller and Juergen A. Knoblich.
Journal of Cell Biology. 2018 Sep 3;217(9):3285-3300.
17.
A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.
Sebastian Wissel, Anja Kieser, Tetsuo Yasugi, Peter Duchek, Elisabeth Roitinger, Joseph Gokcezade, Victoria Steinmann, Ulrike Gaul, Karl Mechtler, Klaus Förstemann, Jürgen A. Knoblich and Ralph A. Neumüller.
G3 (Bethesda). 2016 Aug 9;6(8):2467-78.
16.
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.
Lizabeth A. Perkins, Laura Holderbaum, Rong Tao, Yanhui Hu, Richelle Sopko, Kim McCall, Donghui Yang-Zhou, Ian Flockhart, Richard Binari, Hye-Seok Shim, Audrey Miller, Amy Housden, Marianna Foos, Sakara Randkelv, Colleen Kelley, Pema Namgyal, Christians Villalta, Lu-Ping Liu, Xia Jiang, Qiao Huan-Huan, Xia Wang, Asao Fujiyama, Atsushi Toyoda, Kathleen Ayers, Allison Blum, Benjamin Czech, Ralph A. Neumuller, Dong Yan, Amanda Cavallaro, Karen Hibbard, Don Hall, Lynn Cooley, Gregory J. Hannon, Ruth Lehmann, Annette Parks, Stephanie E. Mohr, Ryu Ueda, Shu Kondo, Jian-Quan Ni and Norbert Perrimon.
Genetics. 2015 Nov;201(3):843-52.
15.
Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila.
Xiankun Zeng, Lili Han, Shree Ram Singh, Hanhan Liu, Ralph A. Neumüller, Dong Yan, Yanhui Hu, Ying Liu, Wei Liu, Xinhua Lin, Steven X. Hou.
Cell Reports. 2015 Feb 24;10(7):1226-38.
14.
RNAi Screening Comes of Age: Enhanced techniques and complementary approaches.
Stephanie Mohr, Jennifer Smith, Caroline Shamu, Ralph A. Neumüller and Norbert Perrimon (2014).
Nature Reviews Molecular Cell Biology. 2014 Sep;15(9):591-600.
13.
Systematic screen of chemotherapeutics in Drosophila stem cell tumors.
Michele Markstein, Samantha Dettorre, Julio Cho, Ralph A. Neumüller, Soeren Craig-Müller and Norbert Perrimon (2014).
Proceedings of the National Academy of Sciences. Mar 25;111(12):4530-5.
12.
A regulatory network of Drosophila germline stem cell self-renewal.
Dong Yan*, Ralph A. Neumüller*, Michael Buckner, Kathleen Ayers, Hua Li, Lei Pan, Xiaoxi Wang, Yanhui Hu, Donghui Yang-Zhou, Arunachalam Vinayagam, Richard Binari, Sakara Randklev, Lizabeth A. Perkins, Ting Xie, Lynn Cooley, and Norbert Perrimon.
Developmental Cell. Feb 24;28(4):459- 73.
(*equal contribution)
11.
Integrating protein- protein interaction networks with phenotypes reveals signs of interactions.
Arunachalam Vinayagam, Jonathan Zirin, Charles Roesel, Yanhui Hu, Anastasia Samsonova, Ralph A. Neumüller, Stephanie E. Mohr and Norbert Perrimon (2013).
Nature Methods. Jan;11(1):94-9.
10.
Conserved regulators of nucleolar size revealed by global phenotypic analyses.
Ralph A. Neumüller*, Thomas Gross*, Anastasia Samsonova, Arunachalam Vinayagam, Michael Buckner, Karen Founk, Yanhui Hu, Brenda Andrews, Fred Winston and Norbert Perrimon (2013).
Science Signaling. Aug 20;6(289):ra70
(*equal contribution)
9.
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes.
Ralph A. Neumüller, Frederik Wirtz-Peitz, Stella Lee, Young Kwon, Michael Buckner, Koen Venken, Hugo Bellen, Stephanie E. Mohr, and Norbert Perrimon (2012).
Genetics. Mar;190(3):931-40
8.
Genome wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.
Ralph A. Neumüller*, Constance Richter*, Anja Fischer*, Maria Novatchkova, Klaus Neumüller and Jürgen A. Knoblich (2011).
Cell Stem Cell. May, 8(5): 580-593
(*equal contribution)
7.
Where gene discovery turns into systems biology: Genome-scale RNAi screens in Drosophila.
Ralph A. Neumüller and Norbert Perrimon (2010).
Wiley Interdiscip. Rev. Syst. Biol. Med. 2010 Dec 31
6.
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer.
Ralph A. Neumüller and Jürgen A. Knoblich (2009).
Genes & Development. 2009 Dec 1;23(23):2675-99
5.
Wicked views on stem cell news.
Ralph A. Neumüller and Jürgen A. Knoblich (2009).
Nature Cell Biology. 11(6):678-9
4.
Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signaling.
Wolfgang Benetka, Norbert Mehlmer, Sebastian Maurer-Stroh, Michaela Sammer, Manfred Koranda, Ralph Neumüller, Jörg Betschinger, Jürgen Knoblich, Markus Teige and Frank Eisenhaber (2008).
Cell Cycle. Dec;7(23):3709-19. 13;8(3)
3.
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.
Ralph A. Neumüller, Jörg Betschinger, Anja Fischer, Natascha Bushati, Ingrid Poernbacher, Karl Mechtler, Stephen M. Cohen and Juergen A. Knoblich (2008).
Nature. 454, 241-245
2.
Phosphoinositide 3-kinase acts through Rac and Cdc42 during agrin-induced acetylcholine receptor clustering.
Viktoria Nizhynska, Ralph Neumueller and Ruth Herbst (2007).
Developmental Neurobiology. 67,8, 1047-1058
1.
The Drosophila NuMA Homolog Mud Regulates Spindle Orientation in Asymmetric Cell Division.
Sarah K. Bowman*, Ralph A. Neumüller*, Maria Novatchkova, Quansheng Du, and Juergen A. Knoblich (2006)
Developmental Cell. 10, 731-742 (*equal contribution)